Natural Factors Methylfolate Plus Methylcobalamin is an innovative one-a-day formula that provides 1000 mcg of folate and 50 mcg of vitamin B12 alongside Farm Fresh Factors® – a bioenergetic blend of phytonutrients – to help prevent folate deficiency. Research has shown that Quatrefolic®, the metabolically active and coenzymated form of folate, results in a 3.1 times higher blood folate concentration of 5-MTHF than regular folic acid. Feel the difference!